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Typically, the apparatus used for the procedure consists of atleast two chambers with distinct characteristics e. In the subsequent section, we will discuss the effects of blocking glutamatergic transmission using pharmacological compounds on behavioral measures of drug reward. Karen K. Interestingly, mu-opioid receptor activation increases postsynaptic NMDA-mediated glutamate transmission via activation of protein kinase C Chen and Huang, ; Martin et al. Therefore, identifying neural substrates that mediate the rewarding effects of drugs of abuse will help in our understanding of processes involved in the development of drug addiction and help in the discovery of medications for its treatment. Operant drug self-administration involves either fixed- or progressive-ratio schedules. NMDA receptors are complex receptors and require binding of glutamate, the co-agonist glycine, and membrane depolarization for removal of a magnesium block. Fixed-ratio schedules, in which the animal has to press a lever or poke its nose into a particular hole a fixed number of times to obtain the drug, are generally used to measure the reinforcing effects of a drug. In summary, psychostimulants like cocaine and nicotine increase glutamate transmission without directly interacting with glutamate receptors. First the effects of glutamate transmission blockade on behavioral measures of drug reward will be discussed.

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Typically, the apparatus used for the procedure consists of atleast two chambers with distinct characteristics e. In the subsequent section, we will discuss the effects of blocking glutamatergic transmission using pharmacological compounds on behavioral measures of drug reward. Karen K. Interestingly, mu-opioid receptor activation increases postsynaptic NMDA-mediated glutamate transmission via activation of protein kinase C Chen and Huang, ; Martin et al. Therefore, identifying neural substrates that mediate the rewarding effects of drugs of abuse will help in our understanding of processes involved in the development of drug addiction and help in the discovery of medications for its treatment. Operant drug self-administration involves either fixed- or progressive-ratio schedules. NMDA receptors are complex receptors and require binding of glutamate, the co-agonist glycine, and membrane depolarization for removal of a magnesium block. Fixed-ratio schedules, in which the animal has to press a lever or poke its nose into a particular hole a fixed number of times to obtain the drug, are generally used to measure the reinforcing effects of a drug. In summary, psychostimulants like cocaine and nicotine increase glutamate transmission without directly interacting with glutamate receptors. First the effects of glutamate transmission blockade on behavioral measures of drug reward will be discussed.

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